House of the Witchdoctor Evil unleashes havoc and murder upon Leslie Van Hooten (Callie Stephens), a beautiful young girl, and her unsuspecting fellow grad students as they make their way to her family's absurd and remote estate. Peter (Bill Mosley) and Irene Van Hooten (Leslie Easterbrook), the young girls mother and father, leave the group alone for the weekend, so that Leslie may mourn the anniversary of her boyfriends shocking murder. But the peaceful weekend soon turns into chaos when the students find themselves being savagely terrorized by Cliff Rifton (Allan Kayser), a crazed, recently-released career criminal, and Buzz Schenk, his drug addict sidekick, who are hell bent on a torturous killing spree. But as the terrifying acts begin to unfold, the killers soon realize all is not as it seems. And when some strangers from the neighborhood show up, the tables are turned. Now everyone is trapped inside and, as the body count begins to rise, it seems that death is now the only real escape from the House of the Witchdoctor.