When everyone's armed and dangerous, one wrong move can get you killed. Enter into the world of seven strangers - each of whom find their lives changed when their fates collide at gunpoint. Helen (Joan Allen) and Warren (Jeff Daniels) Harding are an affluent couple on the brink of divorce. Their separation causes their lives to intersect with eclectic and tormented individuals including a paranoid computer mogul (Gary Sinise), an adulterous lawyer (André Braugher), a disillusioned cop (Robert Forster), a jilted lover (David Schwimmer), a video store manager (Josh Brolin), a street urchin (Anna Paquin) and her schizophrenic brother (Giovanni Ribisi). Through a series of coincidences, this unpredictable story touches the lives of each of these strangers, lovers and acquaintances and examines the anger within US all.