David and Paige Walling (Hugh Laurie-TV series House, Catherine Keener-Where the Wild Things Are) and Terry and Cathy Ostroff (Oliver Platt-Please Give, Allison Janney-The Help) are best friends and neighbors living on Orange Drive in suburban New Jersey. Their comfortable existence goes awry when prodigal daughter Nina Ostroff (Leighton Meester-Date Night), newly broken up with her fiancé, returns home for Thanksgiving after a 5-year absence. Rather than developing an interest in the successful son of her neighbors, Toby Walling (Adam Brody-TV series the O.C.), which would please both families, it's her parents' best friend David who captures Nina's attention. When the connection between Nina and David becomes undeniable, everyone's lives are thrown into upheaval, particularly Vanessa Walling's (Alia Shawkat-TV show Arrested Development), Nina's childhood best friend. It's not long before the ramifications of the affair begin to work on all of the family members in unexpected and hilarious ways, leading everyone to reawaken to their lives and reassess what it means to be happy.