Banished from normal housing for the crime of adopting stray cats, Sorata Kanda's life has gone to the dogs and now he's been impounded in Room 101 of Sakura Hall, a notorious den of troublemakers, geniuses and weirdos. Meanwhile, Mashiro Shiina in Room 202 is the cat's meow of the art world. However, she's so unfocused and dysfunctional that she needs a full-time keeper to survive day-to-day life while she puts her career as a famous artist on hold and studies to be a manga creator. That's too big a task for Chihiro, Mashiro's cousin who lives in the same dorm and also happens to be Sorata's teacher. But given Sorata's weakness for taking in small, cute but sometimes not completely loveable creatures, could he be the one destined to take over Mashiro's grooming, feeding and general, er... domestication? Well, if he's not, too bad, 'cause no one else is stepping up and he's stuck with it and her! Heavy petting gets redefined, the dorm's the only thing likely to get housebroken and hopefully no one will get neutered as who's on whose leash becomes anybodies' guess in the Pet Girl of Sakurasou Collection 1!