Miles "Cain" Skinner (Ving Rhames) is serving a life sentence in prison. A former street kingpin and respected tough guy he is both feared and revered among the inmates in an unforgiving and heartless world. But when he learns that his life is about to be cut short by unforeseen circumstances, Miles must face his toughest challenge yet. Surrounded by a cycle of violence and bloodshed Warden Dean (Robert Patrick) is the only man on the inside that can help Cain with the redemption he seeks. Based on a courageous true story, Wrath of Cain is one man's dedication and drive to put the past behind him and face an uncertain future.