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Ambrogio, the first vampire, has roamed the earth for centuries, haunted by the memory of his lost love, Selene. After countless years of solitude, Ambrogio finds himself in a quiet neighborhood where he encounters Sarah, a young woman who bears an uncanny resemblance to Selene. When his past comes back to haunt him, Ambrogio calls upon the gods to protect her from rivals hellbent on revenge.